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title:	“Droplet-based single-cell joint profiling of histone modifications and transcriptomes”
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  <li>publication
    <h2 id="publication-related-information">publication related information</h2>
    <p>pub:	
authors:	“Yang Xie, Chenxu Zhu, Zhaoning Wang, Melodi Tastemel, Lei Chang, Yang Eric Li &amp; Bing Ren<sup>#</sup>”</p>
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<p>journal:	“Nature Structural &amp; Molecular Biology”
date:	2022
doi:	https://doi.org/10.1038/s41594-023-01060-1
abstract:	“We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at single-cell resolution at scale. However, the lengthy procedure of Paired-Tag has hindered its general adoption in the community. To address this bottleneck, we developed a droplet-based Paired-Tag protocol that is faster and more accessible than the previous method. Using cultured mammalian cells and primary brain tissues, we demonstrate its superior performance at identifying candidate cis-regulatory elements and associating their dynamic chromatin state to target gene expression in each constituent cell type in a complex tissue.”
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